Mass Effect 2 Disc 1 Read Error. Xbox 360. Please Help.?

I have just begun the part of Mass Effect 2 where you must pass through the Omega 4 Relay. Upon my entrance into this new area my game begins to cut-out and lose some audio and video, at the point where I defeat the first drone that breachs into the cargohold it cuts to joker and EDI talking and evading other drones while in the debri field, as EDI says the name "Jeff" an error pops up saying the disc is unreadable and that I should wipe the disc down with a soft cloth (Done) and restart the console (Done). Keep in mind this is a completely new disc absolutely no scratches and I even went to GameStop and picked up a replacement copy. I have installed this disc to my xbox 360 slim's harddrive; I have never had any problems like this previously. Extra Info: My xbox 360 slim is kept horizontal and well ventilated, I can play other parts of the game just fine but not anything within the Omega 4 Relay, again this is disc 1 of 2, and for what its worth I brought Legion and Grunt with me if that matters.